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Publications
publications.htm
Cenix BioScience has participated in the following publications:
Eschenbrenner J, Winsel S, Hammer S, Sommer A, Mittelstaedt K, Drosch M, Klar U, Sachse C,
Hannus M, Seidel M, Weiss B, Merz C, Siemeister G and Hoffmann J. Evaluation of activity and combination strategies with the microtubule-targeting
drug sagopilone in breast cancer cell lines. 2011. Front Oncol 1:44. doi: 10.3389/fonc.2011.00044.
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Abdrakhmanova A, Schlichting R, Hunter CL, Glueckmann M, Lenz C,
Echeverri CJ, Soennichsen B, Jung A, Weiss-Haljiti C. RNAi and iTRAQ reagents united: targeted
quantitation of siRNA-mediated protein silencing in human cells. 2009. Anal Bioanal Chem 395(3):
773-785.
Abstract
Sehm T, Sachse C, Frenzel C, Echeverri K. miR-196 is an essential early-stage
regulator of tail regeneration, upstream of key spinal cord patterning
events. 2009. Dev Biol 334(2):
468-480.
Abstract
Prudencio M, Rodrigues CD, Hannus M, Martin C, Real E,
Gonçalves LA, Carret C, Dorkin R, Röhl I, Jahn-Hoffmann K,
Luty AJ, Sauerwein R, Echeverri CJ, Mota MM.
Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases
in Plasmodium sporozoite infection. 2008. PLoS Pathog 4(11): e1000201.
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text
Puri N, Wang X, Varma R, Burnett C, Beauchamp L,
Batten DM, Young M, Sule V, Latham K, Sendera T, Echeverri C, Sachse C,
Magdaleno S. LNA incorporated
siRNAs exhibit lower off-target effects compared to 2'-OMethoxy in cell
phenotypic assays and microarray analysis. 2008. Nucleic Acids Symp Ser 52: 25-26.
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text
Rodrigues CD, Hannus M, Prudêncio M, Martin
C, Gonçalves LA, Portugal S, Epiphanio S, Akinc A, Hadwiger P,
Jahn-Hofmann K, Röhl I, van Gemert GJ, Franetich JF, Luty AJ,
Sauerwein R, Mazier D, Koteliansky V, Vornlocher HP, Echeverri CJ, Mota
MM. Host Scavenger Receptor SR-BI
Plays a Dual Role in the Establishment of Malaria Parasite Liver
Infection . 2008.
Cell Host & Microbe 4(3):209-218.
Abstract
Sachse C, Weiss-Haljiti C, Holz C, Regener K, Halley F, Hannus M,
Frenzel C, Kluge S, Hewitson M, Bader B, Burd A, Perkins L, Szewczak A,
Prechtl S, Merz C, Rae P, Mumberg D, Echeverri CJ. Exploring the full power of combining high
throughput RNAi with high content readouts: from target discovery
screens to drug modifier studies. In: Haney SA. High Content Screening:
Science, Techniques and Applications. 2008. John Wiley & Sons. pp145-168.
Order
Gottwein E, Mukherjee N, Sachse C, Frenzel C,
Majoros WH, Chi JTA, Braich R, Manoharan M, Soutschek J, Ohler U,
Cullen BR. A viral microRNA functions
as an orthologue of cellular miR-155. 2007. Nature 450: 1096-9.
Abstract
Kittler R, Surendranath V, Heninger AK,
Slabicki M, Theis M, Putz G, Franke K, Caldarelli A, Grabner H, Kozak
K, Wagner J, Rees, Korn B, Frenzel C, Sachse C, Sönnichsen B, Guo
J, Schelter J, Burchard J, Linsley PS, Jackson AL, Habermann B &
Buchholz F. Genome-wide resources of
endoribonuclease-prepared short interfering RNAs for specific
loss-of-function studies. 2007. Nature Methods 4(4):337-44.
Abstract
Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK,
Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL,
Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prévôt B, Root
DE,
Sabatini DM, Taipale J, Perrimon N & Bernards R. Minimizing
the
risk
of
reporting
false positives in large-scale RNAi screens. 2006. Nature Methods 3(10):777-9.
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text
Echeverri CJ, Perrimon N. High-throughput RNAi screening in
cultured cells: a user’s guide. 2006. Nature Reviews
Genetics 7:
373-84.
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text
Ohrt T, Merkle D, Birkenfeld K, Echeverri CJ, Schwille P. In
situ
fluorescence analysis demonstrates active siRNA exclusion from the
nucleus by Exportin 5. 2006.
Nucleic Acids Research 34(5):
1369-80.
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Benn N, Turlais F, Clark V, Jones M, Clulow S. An automated metrics system to measure and
improve the success of laboratory automation implementation.
2006. JALA 11(1): 16-22.
Gunsalus KC, Ge H, Schetter AJ, Goldberg DS, Han JD, Hao T, Berriz GF,
Bertin N, Huang J, Chuang LS, Li N, Mani R, Hyman AA, Sönnichsen
B, Echeverri CJ, Roth FP, Vidal M, Piano F. Predictive models of
molecular machines involved in Caenorhabditis elegans early
embryogenesis. 2005.
Nature 436:
861-5.
Abstract
Krausz E, Pelkmans L, Fava E, Hannus M, Möbius C, Korn K, Halley
F, Lohmann A, Grabner H, Zerial M. Genomweite funktionelle Analyse
des Kinoms
mittels RNA-Interferenz. September 2005. BIOspektrum -
Special
Edition: 518-20.
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text
Pelkmans L, Fava E, Grabner H, Hannus M, Habermann B, Krausz E and
Zerial M. Genome-wide analysis of human kinases in clathrin- and
caveolae/raft-mediated endocytosis. 2005.
Nature 436:
78-86.
Abstract
Koivusalo R, Krausz E, Helenius H, Hietanen S. Chemotherapy compounds in cervical cancer
cells primed by reconstitution of p53 function after short interfering
RNA-mediated degradation of human papillomavirus 18 E6 mRNA: Opposite
effect of siRNA in combination with differentdrugs. 2005. Mol Pharmacol 68: 372-82.
Abstract
Sönnichsen B, Koski LB, Walsh A, Marshall P, Neumann B, Brehm M,
Alleaume A-M, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C,
Khan M, Lazik S, Martin C, Nitschke B, Ruer M, Stamford J, Winzi M,
Heinkel R, Röder M, Finell J, Häntsch H, Jones SJ, Jones M,
Piano F, Gunsalus KC, Oegema K, Gönczy P, Coulson A, Hyman AA,
Echeverri CJ. Full
genome RNAi profiling of early embryogenesis in C. elegans. 2005.
Nature 434:
462-9.
Abstract
Sachse C, Krausz E, Krönke A, Hannus M, Grabner A, Walsh A,
Ovcharenko D, Dorris D, Trudel C, Sönnichsen B, Echeverri CJ. High
throughput
RNA
interference
strategies
for target discovery and
validation by using
synthetic short interfering RNAs: functional genomics investigations of
biological
pathways. 2005. Methods in Enzymology 392: 242-77.
Abstract
Echeverri CJ, Sachse C, Walsh A, Grabner A, Matz C, Brown D. siRNA
Design: auf den Algorithmus kommt es an. 2004. Biospektrum 6: 794-5.
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text
Sachse C, Echeverri CJ. Oncology studies using siRNA libraries:
the dawn of RNAi-based genomics. 2004. Oncogene 23: 8384-91.
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text
Krönke A, Grabner A, Hannus M, Sachse C, Walsh A, Latham K,
Echeverri CJ.
Assessing gene function with siRNA libraries: Kinases affecting cell
proliferation and mitotic index. 2004. PharmaGenomics 11: 37-9.
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Echeverri CJ, Sachse C, Walsh A, Grabner A, Brown D. siRNA
design: It’s all in the algorithm. 2004. Ambion TechNotes
11(3): 14.
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text
Kroenke A, Grabner A, Sachse C, Latham K, Echeverri CJ. Assessing
gene function with siRNA libraries. 2004. Ambion TechNotes
11(3): 11.
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text
Krönke A, Grabner A, Hannus M, Sachse C, Dorris D, Echeverri CJ. Using
RNAi
to
identify
and
validate novel drug targets – Targeting human
kinases with an siRNA library. Drug Discovery World, Spring
2004.
Krausz E, Grabner A, Krönke A, Sachse C, Echeverri CJ. Optimizing
high
throughput
RNAi-based
assays
using transient transfection of
synthetic siRNAs in cultured mammalian cells. In: Engelke DR. RNA
interference (RNAi) – Nuts and bolts of RNAi Technology. 2004. DNA
Press. pp131-168.
Order
Kiger A, Baum B, Jones S, Jones M, Coulson A, Echeverri CJ, Perrimon N.
A functional genomic analysis of cell morphology using RNA
interference. 2003. J Biol. 2: 27.
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Gönczy P, Echeverri CJ, Oegema K, Coulson A, Jones SJ, Copley RR,
Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S,
Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlu N, Bork P,
Hyman AA. Functional genomic analysis of cell division in C.
elegans using RNAi of genes on chromosome III. 2000. Nature
408: 331-6.
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