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Experience Matters:
Over 12 years of High Throughput, High Content Research
Industry's most mature HT-RNAi research specialist offers uniquely comprehensive, streamlined surveys of available delivery solutions and cell lines
Unique Breadth & Depth of Experience & Know-How Optimizing
HT-RNAi Methodologies in Human Cells
Cenix's early entry into the RNAi field, combined with its broad
experience of applying genome-scale RNAi in several experimental
systems from C. elegans to
primary human cells, have yielded the industry's most mature
HT-RNAi-focused research operation.
 The company's long-held focus on HT-RNAi
research has allowed Cenix to
invest extensive time and resources in conducting comprehensive
experimental surveys of a very wide range of siRNA delivery solutions,
from protocols using the multitude of available "lipofection" reagents
(including beta testing of various pre-release reagents) to emerging
HT-electroporation approaches. The resulting optimization of HT-RNAi
silencing protocols was pursued in a wide range of cultured human and
rodent cells chosen for their high industry and disease relevance.
In so doing, Cenix scientists have accumulated the breadth and depth of
experience and know-how that is unique to true specialists. As a
result, our partners benefit from the most mature HT-RNAi protocol
optimization and assay development capabilities available in the
industry today.
Mature Lab & Computing
Infrastructure
Focused on HT-RNAi
- Robotic liquid handling
- Automated HT cell transfection
- HT qRT-PCR analyses
- HT plate readers
- Automated microscopy, image analysis
- Custom-built Lab Info Management System (LIMS)
Basic Analyses
- Silencing Efficacy: qRT-PCR
- Specificity
- Transcriptional profiling
- Target protein levels, localization
- Interferon response, cytotoxicity
Comprehensive Phenotyping Capabilities
- “MultiPlexed” disease-focused and process-focused assays
- Pathway profiling of signal transduction pathways
- Cytological profiling of subcellular components (cytoskeleton,
membranous organelles, nucleus, NE, sub-nuclear structures, etc..)
- Expression profiling
Experienced Know-How Optimizing Partner Assays for HT-RNAi
Screening
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